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Article

Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.

The journals of gerontology. Series A, Biological sciences and medical sciences - 13 Nov 2020

Mandl Markus, Wagner Sonja A, Hatzmann Florian M, Ejaz Asim, Ritthammer Heike, Baumgarten Saphira, Viertler Hans P, Springer Jochen, Zwierzina Marit E, Mattesich Monika, Brucker Camille, Waldegger Petra, Pierer Gerhard, Zwerschke Werner

Abstract excerpt

The role of Ras-Mitogen-activated protein kinase (MAPK) signaling in cellular aging is not precisely understood. Recently, we identified Sprouty1 (SPRY1) as a weight-loss target gene in human adipose stem/progenitor cells (ASCs) and showed that Sprouty1 is important for proper regulation of adipogenesis. In the present study, we show that loss-of-function of Sprouty1 by CRISPR/Cas9-mediated genome editing in...

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Identifiers

PMID: 32304210
DOI: 10.1093/gerona/glaa098
PMCID: PMC7662188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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