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Selective Targeting of Protein Arginine Methyltransferase 1 (PRMT1) Mutant Activity by a Small Molecule Activation Strategy.

ACS chemical biology - 15 May 2026

Dang Tran, Zheng Y George

Abstract excerpt

Protein arginine methyltransferase 1 (PRMT1) is involved in the post-translational modification of cellular proteins in higher organisms by adding a methyl group to arginine-containing substrates. Various studies have demonstrated that the overexpression of PRMT1 is common in cancer development and correlates with poor survival prognosis of patients. Selective targeting of individual PRMT isoforms with chemical...

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Identifiers

PMID: 42048414
DOI: 10.1021/acschembio.6c00073
PMCID: PMC13184939

Genes

PRMT1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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