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Methyltransferase Domain‐Focused Genome Mining for Fungal Polyketide Synthases

21 Apr 2024

Abstract excerpt

A comparison of substrate-binding site amino acid residues in the C-methyltransferase (MT) domains of fungal nonreducing polyketide synthases (NR-PKSs) suggests that these residues are correlated with the methylation modes used by the PKSs. A PKS, designated as AsbPKS, with substrate-binding site residues distinct from those of other known PKSs is focused on. The characterization of AsbPKS revealed that it yields...

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PMID: 38644685
DOI: 10.1002/smtd.202400107

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