Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infection

22 Jul 2013

Abstract excerpt

Experimental and computational evidence suggests that HLAs preferentially bind conserved regions of viral proteins, a concept we term "targeting efficiency," and that this preference may provide improved clearance of infection in several viral systems. To test this hypothesis, T-cell responses to A/H1N1 (2009) were measured from peripheral blood mononuclear cells obtained from a household cohort study performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza Virus Research Studies
Share to T-cell and B-cell Immunology
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23878211
DOI: 10.1073/pnas.1221555110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infectionPMID 23878211Read ↗

CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph.Semantic proximity Read ↗

Epitope specific T-cell responses against influenza A in a healthy population.Semantic proximity Read ↗

CD8<sup>+</sup>T-cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorphSemantic proximity Read ↗

Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph.Semantic proximity Read ↗

Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?Semantic proximity Read ↗

Targets of influenza Human T cell response are mostly conserved in H5N1Semantic proximity Read ↗

Targets of influenza human T-cell response are mostly conserved in H5N1Semantic proximity Read ↗

Long-term adaptation of the influenza A virus by escaping cytotoxic T-cell recognitionSemantic proximity Read ↗

Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?Semantic proximity Read ↗

Conservation and Diversity of Influenza A H1N1 HLA-Restricted T Cell Epitope Candidates for Epitope-Based VaccinesSemantic proximity Read ↗

Quantifying influenza virus diversity and transmission in humans.Semantic proximity Read ↗

Estimating the Binding of Sars-CoV-2 Peptides to HLA Class I in Human Subpopulations Using Artificial Neural NetworksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.