Article

Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?

2018-09-06

Abstract excerpt

The high-degree conservation of CD8 T cell epitopes of influenza A virus (IAV) may allow T cell-inducing vaccines effective across different strains and subtypes. This conservation is not fully explained by functional constraint, since additional mutation(s) can compensate the replicative fitness loss of IAV escape-variant. Here, we propose three additional mechanisms that contribute to the conservation of CD8 T c...

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Literature Corpus work: 3207e5df-712c-5d87-b7f7-e1bf761ab5e5
DOI: 10.1101/408880

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