Article
Quantifying influenza virus diversity and transmission in humans.
Nature genetics - 1 Feb 2016
Poon Leo L M, Song Timothy, Rosenfeld Roni, Lin Xudong, Rogers Matthew B, Zhou Bin, Sebra Robert, Halpin Rebecca A, Guan Yi, Twaddle Alan, DePasse Jay V, Stockwell Timothy B, Wentworth David E, Holmes Edward C, Greenbaum Benjamin, Peiris Joseph S M, Cowling Benjamin J, Ghedin Elodie
Abstract excerpt
Influenza A virus is characterized by high genetic diversity. However, most of what is known about influenza evolution has come from consensus sequences sampled at the epidemiological scale that only represent the dominant virus lineage within each infected host. Less is known about the extent of within-host virus diversity and what proportion of this diversity is transmitted between individuals. To characterize...
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