Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages.

PloS one - 1 Jan 2013

Surdo Matteo, Balestra Emanuela, Saccomandi Patrizia, Di Santo Fabiola, Montano Marco, Di Carlo Domenico, Sarmati Loredana, Aquaro Stefano, Andreoni Massimo, Svicher Valentina, Perno Carlo Federico, Ceccherini-Silberstein Francesca

Abstract excerpt

BACKGROUND: Dual/mixed-tropic HIV-1 strains are predominant in a significant proportion of patients, though little information is available regarding their replication-capacity and susceptibility against CCR5-antagonists in-vitro. The aim of the study was to analyze the replication-capacity and susceptibility to maraviroc of HIV-1 clinical isolates with different tropism characteristics in primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to CCR5 Receptor Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Leukocytes, Mononuclear

Share to Lymphocytes

Share to Macrophages

Share to Receptors, CXCR4

Share to Viral Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 23874501
DOI: 10.1371/journal.pone.0068076
PMCID: PMC3706609

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages.PMID 23874501Read ↗

Maraviroc is able to inhibit dual-R5 viruses in a dual/mixed HIV-1-infected patient.Semantic proximity Read ↗

HIV tropism: diagnostic tools and implications for disease progression and treatment with entry inhibitorsSemantic proximity Read ↗

In vitro phenotypic susceptibility of HIV-1 non-group M to CCR5 inhibitor (maraviroc): TROPI-CO study.Semantic proximity Read ↗

HIV-1 dual/mixed tropic isolates show different genetic and phenotypic characteristics and response to maraviroc in vitroSemantic proximity Read ↗

<i>In vitro</i> phenotypic susceptibility of HIV-1 non-group M to CCR5 inhibitor (Maraviroc): TROPI-CO studySemantic proximity Read ↗

High frequency of X4/DM-tropic viruses in PBMC samples from patients with primary HIV-1 subtype-B infection in 1996-2007: the French ANRS CO06 PRIMO Cohort StudySemantic proximity Read ↗

A sensitive phenotypic assay for the determination of human immunodeficiency virus type 1 tropism.Semantic proximity Read ↗

Prevalence of R5 strains in multi-treated HIV subjects and impact of new regimens including maraviroc in a selected group of patients with CCR5-tropic HIV-1 infection.Semantic proximity Read ↗

Genotypic tropism testing: evidence-based or leap of faith?Semantic proximity Read ↗

Replication capacity, biological phenotype, and drug resistance of HIV strains isolated from patients failing antiretroviral therapy.Semantic proximity Read ↗

Phenotyping methods for determining HIV tropism and applications in clinical settings.Semantic proximity Read ↗

Evaluation of genotypic tropism prediction tests compared with in vitro co-receptor usage in HIV-1 primary isolates of diverse subtypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.