Article
Nonlethal deleterious mutation-induced stress accelerates bacterial aging.
Proceedings of the National Academy of Sciences of the United States of America - 14 May 2024
Kohram Maryam, Sanderson Amy E, Loui Alicia, Thompson Peyton V, Vashistha Harsh, Shomar Aseel, Oltvai Zoltán N, Salman Hanna
Abstract excerpt
Random mutagenesis, including when it leads to loss of gene function, is a key mechanism enabling microorganisms' long-term adaptation to new environments. However, loss-of-function mutations are often deleterious, triggering, in turn, cellular stress and complex homeostatic stress responses, called "allostasis," to promote cell survival. Here, we characterize the differential impacts of 65 nonlethal, deleterious...
Topics
- Escherichia coli
- Stress, Physiological
- Mutation
- Escherichia coli Proteins
- Gene Deletion
- Transcriptome
- Gene Expression Regulation, Bacterial
- Adaptation, Physiological
- Loss of Function Mutation