Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic selection for context-dependent stochastic phenotypes: Sp1 and TATA mutations increase phenotypic noise in HIV-1 gene expression.

PLoS computational biology - 1 Jan 2013

Miller-Jensen Kathryn, Skupsky Ron, Shah Priya S, Arkin Adam P, Schaffer David V

Abstract excerpt

The sequence of a promoter within a genome does not uniquely determine gene expression levels and their variability; rather, promoter sequence can additionally interact with its location in the genome, or genomic context, to shape eukaryotic gene expression. Retroviruses, such as human immunodeficiency virus-1 (HIV), integrate their genomes into those of their host and thereby provide a biomedically-relevant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV-1
Share to In Vitro Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Selection, Genetic

Share to Sp1 Transcription Factor

Share to Stochastic Processes

Share to TATA Box

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 23874178
DOI: 10.1371/journal.pcbi.1003135
PMCID: PMC3708878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic selection for context-dependent stochastic phenotypes: Sp1 and TATA mutations increase phenotypic noise in HIV-1 gene expression.PMID 23874178Read ↗

Phenotypic consequences of promoter-mediated transcriptional noise.Semantic proximity Read ↗

Varying virulence: epigenetic control of expression noise and disease processes.Semantic proximity Read ↗

Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise.Semantic proximity Read ↗

Noise-mean relationship in mutated promoters.Semantic proximity Read ↗

A minimal fate-selection switch.Semantic proximity Read ↗

Control of stochasticity in eukaryotic gene expression.Semantic proximity Read ↗

Impact of viral activators and epigenetic regulators on HIV-1 LTRs containing naturally occurring single nucleotide polymorphisms.Semantic proximity Read ↗

Atlas of HIV cis-regulatory elements reveals extensive transcriptional variation across clades, isolates, and within individualsSemantic proximity Read ↗

A statistical framework for revealing signaling pathways perturbed by DNA variants.Semantic proximity Read ↗

Functional properties of the HIV-1 long terminal repeat containing single-nucleotide polymorphisms in Sp site III and CCAAT/enhancer binding protein site I.Semantic proximity Read ↗

Dynamics of protein noise can distinguish between alternate sources of gene-expression variability.Semantic proximity Read ↗

Stochasticity in gene expression: from theories to phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.