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Article

A statistical framework for revealing signaling pathways perturbed by DNA variants.

Nucleic acids research - 23 Jun 2015

Wilentzik Roni, Gat-Viks Irit

Abstract excerpt

Much of the inter-individual variation in gene expression is triggered via perturbations of signaling networks by DNA variants. We present a novel probabilistic approach for identifying the particular pathways by which DNA variants perturb the signaling network. Our procedure, called PINE, relies on a systematic integration of established biological knowledge of signaling networks with data on transcriptional...

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Identifiers

PMID: 25765646
DOI: 10.1093/nar/gkv203
PMCID: PMC4477643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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