Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of viral activators and epigenetic regulators on HIV-1 LTRs containing naturally occurring single nucleotide polymorphisms.

BioMed research international - 1 Jan 2015

Shah Sonia, Pirrone Vanessa, Alexaki Aikaterini, Nonnemacher Michael R, Wigdahl Brian

Abstract excerpt

Following human immunodeficiency virus type 1 (HIV-1) integration into host cell DNA, the viral promoter can become transcriptionally silent in the absence of appropriate signals and factors. HIV-1 gene expression is dependent on regulatory elements contained within the long terminal repeat (LTR) that drive the synthesis of viral RNAs and proteins through interaction with multiple host and viral factors. Previous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clone Cells
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Hematopoietic Stem Cells

Share to HIV Long Terminal Repeat

Share to Hydroxamic Acids

Share to Interleukin-1beta

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 25629043
DOI: 10.1155/2015/320642
PMCID: PMC4299542

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of viral activators and epigenetic regulators on HIV-1 LTRs containing naturally occurring single nucleotide polymorphisms.PMID 25629043Read ↗

Functional properties of the HIV-1 long terminal repeat containing single-nucleotide polymorphisms in Sp site III and CCAAT/enhancer binding protein site I.Semantic proximity Read ↗

Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomes.Semantic proximity Read ↗

Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomesSemantic proximity Read ↗

Divergent transcriptional regulation among expanding human immunodeficiency virus type 1 subtypesSemantic proximity Read ↗

Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment.Semantic proximity Read ↗

Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review).Semantic proximity Read ↗

HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.Semantic proximity Read ↗

Genotypic and phenotypic characterization of long terminal repeat sequences from long-term survivors of human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Genetic selection for context-dependent stochastic phenotypes: Sp1 and TATA mutations increase phenotypic noise in HIV-1 gene expression.Semantic proximity Read ↗

Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression.Semantic proximity Read ↗

Naturally occurring genotypes of the human immunodeficiency virus type 1 long terminal repeat display a wide range of basal and Tat-induced transcriptional activities.Semantic proximity Read ↗

The evolution of regulatory elements in the emerging promoter variant strains of HIV-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.