Article
Noise-mean relationship in mutated promoters.
Genome research - 1 Dec 2012
Hornung Gil, Bar-Ziv Raz, Rosin Dalia, Tokuriki Nobuhiko, Tawfik Dan S, Oren Moshe, Barkai Naama
Abstract excerpt
Gene expression depends on the frequency of transcription events (burst frequency) and on the number of mRNA molecules made per event (burst size). Both processes are encoded in promoter sequence, yet their dependence on mutations is poorly understood. Theory suggests that burst size and frequenc...
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