Article
Nicotine increases lifespan and rescues olfactory and motor deficits in a Drosophila model of Parkinson's disease.
Behavioural brain research - 15 Sept 2013
Chambers Raegan P, Call Gerald B, Meyer David, Smith Justin, Techau Jared A, Pearman Krista, Buhlman Lori M
Abstract excerpt
Drosophila melanogaster is an attractive model of familial Parkinson's disease, as flies with loss-of-function mutations of the parkin gene exhibit many pathologies observed in PD patients. Progressive motor deficits found in homozygous parkin mutants seem to result from mitochondrial pathology that causes indirect flight muscle and dopaminergic neuronal degeneration [1,2]. We have found that heterozygous parkin...
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