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Article

Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors

16 Jul 2015

Abstract excerpt

Multiple neurological disorders are characterized by the abnormal accumulation of protein aggregates and the progressive impairment of complex behaviors. Our Drosophila studies demonstrate that middle-aged wild-type flies (WT, ~4-weeks) exhibit a marked accumulation of neural aggregates that is commensurate with the decline of the autophagy pathway. However, enhancing autophagy via neuronal over-expression of...

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PMID: 26182057
DOI: 10.1371/journal.pone.0132768

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