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Article

Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish

18 Jul 2013

Abstract excerpt

The melanocortin-4 receptor (MC4R) is essential for control of energy homeostasis in vertebrates. MC4R interacts with melanocortin receptor accessory protein 2 (MRAP2) in vitro, but its functions in vivo are unknown. We found that MRAP2a, a larval form, stimulates growth of zebrafish by specifically blocking the action of MC4R. In cell culture, this protein binds MC4R and reduces the ability of the receptor to...

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PMID: 23869017
DOI: 10.1126/science.1232995

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