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Article

Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer

19 Jul 2013

Abstract excerpt

About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid receptor alpha as a marker of tamoxifen resistance. Using quantitative mass spectrometry-based proteomics, we show that retinoic acid receptor alpha protein networks and levels differ in a tamoxifen-sensitive (MCF7) and a tamoxifen-resistant (LCC2) cell...

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PMID: 23868472
DOI: 10.1038/ncomms3175

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