Article

Retinoic Acid Sensitivity of Triple-Negative Breast-Cancer Cells Characterized by Constitutive Activation of the NOTCH1 Pathway: The Role of RARβ

2020-08-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> All-trans retinoic-acid (ATRA) is a promising agent in the personalized treatment/chemo-prevention of breast-cancer. Triple-negative breast-cancer (<italic>TNBC</italic>) accounts for 15-20% of all mammary tumours and share common features such as a high proliferation index and a basal-like gene expression signature. In spite of this, <italic>TNBC</italic> is ve...

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Literature Corpus work: cd9a0759-9664-5d74-a311-bd214284523f
DOI: 10.21203/rs.3.rs-53959/v1

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