Article
Differential gene expression in tamoxifen-resistant breast cancer cells revealed by a new analytical model of RNA-Seq data.
PloS one - 1 Jan 2012
Huber-Keener Kathryn J, Liu Xiuping, Wang Zhong, Wang Yaqun, Freeman Willard, Wu Song, Planas-Silva Maricarmen D, Ren Xingcong, Cheng Yan, Zhang Yi, Vrana Kent, Liu Chang-Gong, Yang Jin-Ming, Wu Rongling
Abstract excerpt
Resistance to tamoxifen (Tam), a widely used antagonist of the estrogen receptor (ER), is a common obstacle to successful breast cancer treatment. While adjuvant therapy with Tam has been shown to significantly decrease the rate of disease recurrence and mortality, recurrent disease occurs in one third of patients treated with Tam within 5 years of therapy. A better understanding of gene expression alterations...
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