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Article

Alteration in protein expression in estrogen receptor alpha-negative human breast cancer tissues indicates a malignant and metastatic phenotype.

Clinical & experimental metastasis - 1 Oct 2010

Sahab Ziad J, Man Yan-Gao, Semaan Suzan M, Newcomer Robert G, Byers Stephen W, Sang Qing-Xiang Amy

Abstract excerpt

Ductal carcinoma in situ (DCIS) represents the earliest identifiable breast cancer lesion. Disruption of the myoepithelial cell layer and basement membrane is a prerequisite for DCIS to initiate invasion into the stroma. The majority of epithelial cells overlying a focally-disrupted myoepithelial cell layer are estrogen receptor-alpha negative (ER(-)); however, adjacent cells within the same duct confined by an...

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Identifiers

PMID: 20602252
DOI: 10.1007/s10585-010-9338-8
PMCID: PMC4346338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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