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Article

Prefrontal brain responsiveness to negative stimuli distinguishes familial risk for major depression from acute disorder.

Journal of psychiatry & neuroscience : JPN - 1 Sept 2017

Opel Nils, Redlich Ronny, Grotegerd Dominik, Dohm Katharina, Zaremba Dario, Meinert Susanne, Bürger Christian, Plümpe Leonie, Alferink Judith, Heindel Walter, Kugel Harald, Zwanzger Peter, Arolt Volker, Dannlowski Udo

Abstract excerpt

BACKGROUND: Identifying reliable trait markers of familial risk for major depressive disorder (MDD) is a challenge in translational psychiatric research. In individuals with acute MDD, dysfunctional connectivity patterns of prefrontal areas have been shown repeatedly. However, it has been unclear in which neuronal networks functional alterations in individuals at familial risk for MDD might be present and to what...

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Identifiers

PMID: 28606245
DOI: 10.1503/jpn.160198
PMCID: PMC5573576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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