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Article

Ventral prefrontal serotonin 1A receptor binding: a neural marker of vulnerability for mood disorder and suicidal behavior?

Molecular psychiatry - 1 Oct 2022

Pantazatos Spiro P, Melhem Nadine M, Brent David A, Zanderigo Francesca, Bartlett Elizabeth A, Lesanpezeshki Mohammad, Burke Ainsley, Miller Jeffrey M, Mann J John

Abstract excerpt

Mood disorders and suicidal behavior have moderate heritability and are associated with altered corticolimbic serotonin 1A receptor (5-HT1A) brain binding. However, it is unclear whether this reflects genetic effects or epigenetic effects of childhood adversity, compensatory mechanisms, or illness stress-related changes. We sought to separate such effects on 5-HT1A binding by examining high familial risk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35760877
DOI: 10.1038/s41380-022-01671-y
PMCID: PMC9722608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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