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Article

Mode of virus rescue determines the acquisition of VHS mutations in VP22-negative herpes simplex virus 1.

Journal of virology - 1 Sept 2013

Ebert Katja, Depledge Daniel P, Breuer Judith, Harman Laura, Elliott Gillian

Abstract excerpt

It has been proposed that herpes simplex virus 1 with VP22 deleted requires secondary mutation of VHS for viability. Here we show that a replication-competent Δ22 virus constructed by homologous recombination maintains a wild-type (Wt) VHS gene and has no other gross mutations. By contrast, Δ22 viruses recovered from a bacterial artificial chromosome contain multiple amino acid changes within a conserved region...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23864617
DOI: 10.1128/JVI.01654-13
PMCID: PMC3753997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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