Article
Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes neurovirulence.
Journal of virology - 1 May 2012
Tanaka Michiko, Kato Akihisa, Satoh Yuko, Ide Takahiro, Sagou Ken, Kimura Kayo, Hasegawa Hideki, Kawaguchi Yasushi
Abstract excerpt
Herpes simplex virus 1 (HSV-1) protein VP22, encoded by the UL49 gene, is a major virion tegument protein. In the present study, we showed that VP22 was required for efficient redistribution of viral proteins VP16, VP26, ICP0, ICP4, and ICP27 and of cellular protein Hsc-70 to the cytoplasm of infected cells. We found that two dileucine motifs in VP22, at amino acids 235 and 236 and amino acids 251 and 252, were...
Topics
- Amino Acid Motifs
- Amino Acid Substitution
- Animals
- Brain
- Cell Line
- Chlorocebus aethiops
- Female
- Gene Order
- Genome, Viral
- Herpes Simplex Virus Protein Vmw65
- Herpesvirus 1, Human
- Leucine
- Mice
- Mice, Inbred ICR