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Article

Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes neurovirulence.

Journal of virology - 1 May 2012

Tanaka Michiko, Kato Akihisa, Satoh Yuko, Ide Takahiro, Sagou Ken, Kimura Kayo, Hasegawa Hideki, Kawaguchi Yasushi

Abstract excerpt

Herpes simplex virus 1 (HSV-1) protein VP22, encoded by the UL49 gene, is a major virion tegument protein. In the present study, we showed that VP22 was required for efficient redistribution of viral proteins VP16, VP26, ICP0, ICP4, and ICP27 and of cellular protein Hsc-70 to the cytoplasm of infected cells. We found that two dileucine motifs in VP22, at amino acids 235 and 236 and amino acids 251 and 252, were...

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Identifiers

PMID: 22357273
DOI: 10.1128/JVI.06913-11
PMCID: PMC3347367

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes neurovirulence.PMID 22357273Read ↗

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