Herpes simplex virus 1 strain 17+ with R2 mutation in UL37 has residual retrograde transport.

doi:10.1128/spectrum.01959-25

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Article

Herpes simplex virus 1 strain 17+ with R2 mutation in UL37 has residual retrograde transport.

Microbiology spectrum - 6 Jan 2026

Walter Marius, Haick Anoria K, Massa Paola A, Klouser Lindsay M, Stensland Laurence, Santo Tracy K, Xie Hong, Jerome Keith R

Abstract excerpt

Herpes simplex virus 1 (HSV-1) causes lifelong recurrent infections. Following primary infection of the oral or genital mucosa, HSV-1 travels retrogradely through axons and establishes latency in the cell body of ganglionic neurons of the peripheral nervous system. Periodic reactivation in neurons and anterograde transport of virions back to peripheral regions cause oral or genital ulcerations. Many host and...

Topics

Herpesvirus 1, Human
Animals
Mice
Female
Herpes Simplex
Mutation
Viral Structural Proteins
Virus Latency
Disease Models, Animal
Amino Acid Substitution
Humans
Vero Cells

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Identifiers

PMID: 41334909
DOI: 10.1128/spectrum.01959-25
PMCID: PMC12772277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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