Article
The impact of genetic background and cell lineage on the level and pattern of gene expression in position effect variegation.
Epigenetics & chromatin - 13 Nov 2019
Wang Sidney H, Elgin Sarah C R
Abstract excerpt
BACKGROUND: Chromatin-based transcriptional silencing is often described as a stochastic process, largely because of the mosaic expression observed in position effect variegation (PEV), where a euchromatic reporter gene is silenced in some cells as a consequence of juxtaposition with heterochromatin. High levels of variation in PEV phenotypes are commonly observed in reporter stocks. To ascertain whether...
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