Article
Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations.
PloS one - 1 Jan 2013
Ngaimisi Eliford, Habtewold Abiy, Minzi Omary, Makonnen Eyasu, Mugusi Sabina, Amogne Wondwossen, Yimer Getnet, Riedel Klaus-Dieter, Janabi Mohammed, Aderaye Getachew, Mugusi Ferdinand, Bertilsson Leif, Aklillu Eleni, Burhenne Juergen
Abstract excerpt
OBJECTIVES: We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two African populations. METHODS: ART naïve HIV patients from Ethiopia (n = 285) and Tanzania (n = 209) were prospectively enrolled in parallel to start efavirenz based HAART. CD4+ cell counts were determined at baseline, 12, 24 and 48 weeks....
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