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Article

A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single‐dose efavirenz population pharmacokinetics in Ugandans

7 Aug 2009

Abstract excerpt

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Efavirenz is metabolized by highly polymorphic enzymes, CYP2B6 and CYP3A. The effect of the different variant alleles on efavirenz population pharmacokinetics has not yet been fully explored. • CYP2B6*6 influences efavirenz steady‐state pharmacokinetics. Together with sex it explains 11% of the between‐subject variability in apparent oral clearance, but predictions could...

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PMID: 19916993
DOI: 10.1111/j.1365-2125.2009.03516.x

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