Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclooxygenase 2 genetic polymorphism may increase the risk of developing leukoaraiosis in Chinese.

Journal of molecular neuroscience : MN - 1 Oct 2013

Shan Xiao-yun, Chen Guo-zhong, Cheng Gan-ping, Tao Hong-miao

Abstract excerpt

Cyclooxygenase-2 (COX-2) is a key enzyme involved in the conversion of arachidonic acid into prostaglandins, which are important mediators of inflammation. To clarify the role of inflammation in the pathogenesis of cerebral small vessel disease (SVD), we investigate the possible modulating effect of the functional COX-2 polymorphisms -1195G > A (rs689466) and -765G > C (rs20417) on the risk for development of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Case-Control Studies

Share to Cyclooxygenase 2

Share to Haplotypes

Share to Heterozygote

Share to Linkage Disequilibrium

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 23852948
DOI: 10.1007/s12031-013-0066-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclooxygenase 2 genetic polymorphism may increase the risk of developing leukoaraiosis in Chinese.PMID 23852948Read ↗

Cyclooxygenase-2 genetic polymorphism and stroke subtypes in Chinese.Semantic proximity Read ↗

Influence of the Cyclooxygenase-2 Gene -765G/C and -1195G/A Polymorphisms on Development of Ischemic Stroke.Semantic proximity Read ↗

Correlation of matrix metalloproteinase-2 single nucleotide polymorphisms with the risk of small vessel disease (SVD).Semantic proximity Read ↗

Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients.Semantic proximity Read ↗

Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population.Semantic proximity Read ↗

The COX-2 G/C -765 polymorphism may modulate the occurrence of cerebrovascular ischemia.Semantic proximity Read ↗

Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: a meta-analysis.Semantic proximity Read ↗

Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population.Semantic proximity Read ↗

A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke.Semantic proximity Read ↗

TGF-beta 1 codon 10 polymorphism is associated with cerebral SVD.Semantic proximity Read ↗

Association study of polymorphisms in the cyclooxygenase-2 gene and Alzheimer's disease risk in Chinese.Semantic proximity Read ↗

The association between thromboxane A2 receptor gene polymorphisms and the risk of cerebral infarction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.