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Article

A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke.

JAMA - 12 May 2004

Cipollone Francesco, Toniato Elena, Martinotti Stefano, Fazia Maria, Iezzi Annalisa, Cuccurullo Chiara, Pini Barbara, Ursi Sebastiano, Vitullo Gianfranco, Averna Maurizio, Arca Marcello, Montali Anna, Campagna Filomena, Ucchino Sante, Spigonardo Francesco, Taddei Stefano, Virdis Agostino, Ciabattoni Giovanni, Notarbartolo Alberto, Cuccurullo Franco, Mezzetti Andrea

Abstract excerpt

CONTEXT: Myocardial infarction (MI) and ischemic stroke are thought to be caused by matrix digestion by metalloproteinases (MMPs) leading to rupture of atherosclerotic plaques. Production of macrophage MMP-2 and MMP-9 is induced by cyclooxygenase 2 (COX-2) and prostaglandin E(2) synthesis. Although COX-2 expression may be genetically determined, the relation between COX-2 polymorphisms and the risk of MI and...

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Identifiers

PMID: 15138244
DOI: 10.1001/jama.291.18.2221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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