Article
TGF-beta 1 codon 10 polymorphism is associated with cerebral SVD.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 Nov 2011
Tao Hong-miao, Chen Guo-zhong, Lu Xiao-dong, Hu Xiao-gang, Chen Gan-ping, Shao Bei
Abstract excerpt
BACKGROUND: To clarify the role of inflammation in the pathogenesis of cerebral small vessel disease (SVD), we investigated whether the gene encoding transforming growth factor-beta 1(TGF-beta 1) is a risk factor for cerebral SVD as a whole, and for two different SVD subtypes. METHODS: TGF-beta 1 codon10 (T+29C) genotype was determined in 441 Chinese patients (313 male and 128 female) with cerebral SVD and 450...
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