Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients.

European journal of neurology - 1 Jun 2011

Fernandez-Cadenas I, Mendioroz M, Domingues-Montanari S, Del Rio-Espinola A, Delgado P, Ruiz A, Hernandez-Guillamon M, Giralt D, Chacon P, Navarro-Sobrino M, Ribo M, Molina C A, Alvarez-Sabin J, Rosell A, Montaner J

Abstract excerpt

BACKGROUND: The biologic agents causing leukoaraiosis are unknown. Our aim was to study the genetic basis of leukoaraiosis. METHODS: We analyzed 212 single nucleotide polymorphisms (SNPs) in 142 patients with ischaemic stroke, generating a total of 30,104 genotypes. Seventy-nine subjects (55.6%) presented leukoaraiosis measured by the Fazekas scale and 69 (48.6%) by ARWMC scale. We analyzed the presence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood-Brain Barrier

Share to Brain Ischemia

Share to Gene Expression Regulation

Share to Homeostasis

Share to Risk Factors

Share to Stroke

Source

Identifiers

PMID: 21122033
DOI: 10.1111/j.1468-1331.2010.03243.x

Genes

ITGB6
MMP13
NOS3
PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients.PMID 21122033Read ↗

Inflammatory cytokines are associated with stroke and risk factors of cerebrovascular diseases: a Mendelian randomization study.Semantic proximity Read ↗

An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes.Semantic proximity Read ↗

Identification of key genes for secondary stroke in patients with periodontitisSemantic proximity Read ↗

Polymorphisms in genes related to inflammation and endothelial function are associated with ischemic stroke and other vascular events in populations at high risk of stroke Short title: A community-based survey and cohort study in southwestern ChinaSemantic proximity Read ↗

Gene-gene and gene-environment interplay represent specific susceptibility for different types of ischaemic stroke and leukoaraiosis.Semantic proximity Read ↗

Identification of molecular subtypes of ischaemic stroke based on immune‐related genes and weighted co‐expression network analysisSemantic proximity Read ↗

Genomic biomarkers and cellular pathways of ischemic stroke by RNA gene expression profilingSemantic proximity Read ↗

Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood ProteomeSemantic proximity Read ↗

Genetic Aspects of Inflammation and Immune Response in Stroke.Semantic proximity Read ↗

Association of a Multigenetic Pro-Inflammatory Profile with Ischaemic Stroke.Semantic proximity Read ↗

Heritability of Leukoaraiosis in Hypertensive SibshipsSemantic proximity Read ↗

Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.