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Article

SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer

7 Nov 2017

Abstract excerpt

Objective To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. Design We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expression Omnibus (GEO) database. Functional analysis of SRSF6 in CRC was performed in vitro and in...

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PMID: 29114070
DOI: 10.1136/gutjnl-2017-314983

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