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Article

A patient-derived xenograft mouse model generated from primary cultured cells recapitulates patient tumors phenotypically and genetically.

Journal of cancer research and clinical oncology - 1 Sept 2013

Seol Hyang Sook, Suh Young-Ah, Ryu Young-Joon, Kim Hyun Jung, Chun Sung Min, Na Deuk Chae, Fukamachi Hiroshi, Jeong Seong-Yun, Choi Eun Kyung, Jang Se Jin

Abstract excerpt

BACKGROUND: Preclinical trials of cancer therapeutics require both in vitro and in vivo evaluations. Recently, a patient-derived xenograft model in immunodeficient mice has been reported as a valuable in vivo evaluation system. In our current study, we aimed to establish a more efficient and accurate system for preclinical trials by generating primary cancer cells from patients and performing xenograft transfers...

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Source

Identifiers

PMID: 23817694
DOI: 10.1007/s00432-013-1449-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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