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Article

Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma.

Molecular cancer therapeutics - 1 Aug 2017

Weeden Clare E, Holik Aliaksei Z, Young Richard J, Ma Stephen B, Garnier Jean-Marc, Fox Stephen B, Antippa Phillip, Irving Louis B, Steinfort Daniel P, Wright Gavin M, Russell Prudence A, Ritchie Matthew E, Burns Christopher J, Solomon Benjamin, Asselin-Labat Marie-Liesse

Abstract excerpt

Lung squamous cell carcinoma (SqCC) is a molecularly complex and genomically unstable disease. No targeted therapy is currently approved for lung SqCC, although potential oncogenic drivers of SqCC have been identified, including amplification of the fibroblast growth factor receptor 1 (FGFR1). Reports from a recently completed clinical trial indicate low response rates in patients treated with FGFR tyrosine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Fibroblast Growth Factor, Type 1

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Source

Identifiers

PMID: 28611104
DOI: 10.1158/1535-7163.MCT-17-0174

Genes

FGFR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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