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Article

Increased caveolin-1 in intervertebral disc degeneration facilitates repair.

Arthritis research & therapy - 3 Mar 2016

Bach Frances C, Zhang Ying, Miranda-Bedate Alberto, Verdonschot Lucy C, Bergknut Niklas, Creemers Laura B, Ito Keita, Sakai Daisuke, Chan Danny, Meij Björn P, Tryfonidou Marianna A

Abstract excerpt

BACKGROUND: Preceding intervertebral disc (IVD) degeneration, the cell phenotype in the nucleus pulposus (NP) shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs). Microarray analysis showed a correlation between caveolin-1 expression and the phenotypic transition of NCs to CLCs. With a clinical directive in mind, the aim of this study was to determine the role of caveolin-1 in IVD degeneration....

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Identifiers

PMID: 26939667
DOI: 10.1186/s13075-016-0960-y
PMCID: PMC4778307

Genes

IVD
CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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