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Article

The matricellular protein CCN1 is essential for cardiac development.

Circulation research - 27 Oct 2006

Mo Fan-E, Lau Lester F

Abstract excerpt

The matricellular protein CCN1 (formerly named CYR61) regulates cell adhesion, migration, proliferation, survival, and differentiation through binding to integrin receptors and heparan sulfate proteoglycans. Here we show that Ccn1-null mice are impaired in cardiac valvuloseptal morphogenesis, res...

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Share to Endocardium
Share to Heart Septal Defects
Share to Heart Septal Defects, Atrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Valves

Share to Immediate-Early Proteins

Share to Matrix Metalloproteinase 2

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Source

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Identifiers

PMID: 17023674
DOI: 10.1161/01.RES.0000248426.35019.89
PMCID: PMC1626492

Genes

CCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17023674-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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The matricellular protein CCN1 is essential for cardiac development.PMID 17023674Read ↗

CCN1 mutation is associated with atrial septal defect.Semantic proximity Read ↗

CYR61 (CCN1) is essential for placental development and vascular integrity.Semantic proximity Read ↗

The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis.Semantic proximity Read ↗

Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities.Semantic proximity Read ↗

Construction and Analysis of an Allelic Series of Ccn1 Knockin Mice.Semantic proximity Read ↗

Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) geneSemantic proximity Read ↗

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.Semantic proximity Read ↗

Impaired Intervertebral Disc Development and Premature Disc Degeneration in Mice With Notochord‐Specific Deletion of CCN2Semantic proximity Read ↗

Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossificationSemantic proximity Read ↗

The Matricellular Protein Cysteine-rich Protein 61 (CCN1/Cyr61) Enhances Physiological Adaptation of Retinal Vessels and Reduces Pathological Neovascularization Associated with Ischemic RetinopathySemantic proximity Read ↗

Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteinsSemantic proximity Read ↗

Galnt1 Is Required for Normal Heart Valve Development and Cardiac FunctionSemantic proximity Read ↗

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