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Article

Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Aug 2016

Tang Xinyan, Jing Liufang, Richardson William J, Isaacs Robert E, Fitch Robert D, Brown Christopher R, Erickson Melissa M, Setton Lori A, Chen Jun

Abstract excerpt

Previous study claimed that disc degeneration may be preceded by structure and matrix changes in the intervertebral disc (IVD) which coincide with the loss of distinct notochordally derived nucleus pulposus (NP) cells. However, the fate of notochordal cells and their molecular phenotype change during aging and degeneration in human are still unknown. In this study, a set of novel molecular phenotype markers of...

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Identifiers

PMID: 27018499
DOI: 10.1002/jor.23244
PMCID: PMC5321132

Genes

IVD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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