Article
A study on the association of cytochrome-P450 1A1 polymorphism and breast cancer risk in north Indian women.
Breast cancer research and treatment - 1 Jan 2007
Singh Virendra, Rastogi Neeraj, Sinha Ashima, Kumar Abhai, Mathur Neeraj, Singh Mahendra Pratap
Abstract excerpt
Cytochrome P-450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogens and mammary carcinogens into 2-hydroxy catechol metabolites. Many commonly occurring single nucleotide polymorphism (SNP) are reported in CYP1A1 in various populations that include, isoleucine to valine substitution at 462 codon in heme binding region in exon 7 (A to G transition at position 2455; M2), threonine to asparagine...
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