A study on the association of cytochrome-P450 1A1 polymorphism and breast cancer risk in north Indian women.

doi:10.1007/s10549-006-9264-2

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Article

A study on the association of cytochrome-P450 1A1 polymorphism and breast cancer risk in north Indian women.

Breast cancer research and treatment - 1 Jan 2007

Singh Virendra, Rastogi Neeraj, Sinha Ashima, Kumar Abhai, Mathur Neeraj, Singh Mahendra Pratap

Abstract excerpt

Cytochrome P-450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogens and mammary carcinogens into 2-hydroxy catechol metabolites. Many commonly occurring single nucleotide polymorphism (SNP) are reported in CYP1A1 in various populations that include, isoleucine to valine substitution at 462 codon in heme binding region in exon 7 (A to G transition at position 2455; M2), threonine to asparagine...

Topics

Adult
Breast Neoplasms
Catalysis
Chi-Square Distribution
Cytochrome P-450 CYP1A1
Female
Gene Expression Profiling
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
India
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 16807674
DOI: 10.1007/s10549-006-9264-2

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