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Genetic polymorphisms of drug-metabolizing phase I enzymes CYP2E1, CYP2A6 and CYP3A5 in South Indian population.

Fundamental & clinical pharmacology - 1 Apr 2012

Krishnakumar D, Gurusamy Umamaheswaran, Dhandapani Kayathri, Surendiran A, Baghel Ruchi, Kukreti Ritushree, Gangadhar Reneega, Prayaga Ushakiran, Manjunath S, Adithan C

Abstract excerpt

CYP2E1, CYP2A6 and CYP3A5 enzymes belong to phase I group of drug-metabolizing enzymes, which are involved in the metabolism of various compounds and xenobiotics. Presence of polymorphisms in the genes coding for these enzymes results in interindividual variations in drug metabolism, therapeutic response and susceptibility towards various diseases. The frequencies of these variants in genes differ considerably...

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PMID: 21265876
DOI: 10.1111/j.1472-8206.2010.00917.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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