Article
Frequency distribution of high risk alleles of CYP2C19, CYP2E1, CYP3A4 genes in Haryana population.
Environmental toxicology and pharmacology - 1 May 2014
Gulati Sachin, Yadav Anita, Kumar Neeraj, Kanupriya, Kumar Gaurav, Aggarwal Neeraj, Gupta Ranjan
Abstract excerpt
The genotype of an individual can significantly influence the disposition of a chemical, and determine their susceptibility to its toxicity. Many enzymes involved in either activation or detoxification of chemical carcinogen metabolism are polymorphically expressed, with the alleles presenting different enzymatic activities and some of them having been associated with susceptibility to cancer. Cytochrome P450...
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