Article
Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia but not dysplasia.
Cells, tissues, organs - 1 Jan 2013
Komaki Fumiyo, Miyazaki Yoichi, Niimura Fumio, Matsusaka Taiji, Ichikawa Iekuni, Motojima Masaru
Abstract excerpt
BACKGROUND: Mice carrying the null-mutated Foxc1 gene frequently develop an anomalous double collecting system. These mice provide an ideal opportunity to specify the role of ectopic budding in the development of congenital anomalies of the kidney and urinary tract. METHODS: Tissue specimens were collected from Foxc1(ch/ch) mutants at several embryonic stages and at birth. The upper and lower pole kidneys were...
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