Article
Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development.
Development (Cambridge, England) - 1 Feb 2005
Levinson Randy S, Batourina Ekatherina, Choi Christopher, Vorontchikhina Marina, Kitajewski Jan, Mendelsohn Cathy L
Abstract excerpt
Development of the metanephric kidney involves the establishment of discrete zones of induction and differentiation that are crucial to the future radial patterning of the organ. Genetic deletion of the forkhead transcription factor, Foxd1, results in striking renal abnormalities, including the loss of these discrete zones and pelvic fused kidneys. We have investigated the molecular and cellular basis of the...
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