Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation

26 Jan 2012

Abstract excerpt

Intraflagellar transport (IFT) complexes A and B build and maintain primary cilia. In the mouse, kidney-specific or hypomorphic mutant alleles of IFT complex B genes cause polycystic kidneys, but the influence of IFT complex A proteins on renal development is not well understood. In the present study, we found that HoxB7-Cre-driven deletion of the complex A gene Ift140 from collecting ducts disrupted, but did not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fetal and Pediatric Neurological Disorders
Share to Genetic and Kidney Cyst Diseases
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22282595
DOI: 10.1681/asn.2011080829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle MisorientationPMID 22282595Read ↗

Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney diseaseSemantic proximity Read ↗

Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development.Semantic proximity Read ↗

Inactivation of <i>Nphp2</i> in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouseSemantic proximity Read ↗

Impaired centrosome biogenesis in kidney stromal progenitors reduces abundance of interstitial lineages and accelerates injury-induced fibrosisSemantic proximity Read ↗

Wnt and planar cell polarity signaling in cystic renal diseaseSemantic proximity Read ↗

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney.Semantic proximity Read ↗

mtor Haploinsufficiency Ameliorates Renal Cysts and Cilia Abnormality in Adult Zebrafish tmem67 MutantsSemantic proximity Read ↗

IFT-A deficiency in juvenile mice impairs biliary development and exacerbates ADPKD liver diseaseSemantic proximity Read ↗

Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.Semantic proximity Read ↗

Defects in ciliary localization of Nek8 is associated with cystogenesis.Semantic proximity Read ↗

Disruption of Core Planar Cell Polarity Signaling Regulates Renal Tubule Morphogenesis but Is Not CystogenicSemantic proximity Read ↗

Ciliary ARL13B drives renal cystogenesis via its GEF activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.