Article
Ontogeny of congenital anomalies of the kidney and urinary tract, CAKUT.
Pediatrics international : official journal of the Japan Pediatric Society - 1 Oct 2003
Miyazaki Yoichi, Ichikawa Iekuni
Abstract excerpt
Ectopic budding of the initial ureter from the Wolffian duct is the first ontogenic misstep that leads to many congenital anomalies of the kidney and urinary tract (CAKUT). The ectopia results in hypoplastic kidney, ectopia of ureterovesical orifice, urinary outflow obstruction and/or reflux. Recent studies on several mutant mouse models verified that ectopic ureteric budding indeed occurs prior to the formation...
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