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Article

Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/-) hearts.

The Journal of physiology - 1 Sept 2013

Matthews Gareth D K, Guzadhur Laila, Sabir Ian N, Grace Andrew A, Huang Christopher L-H

Abstract excerpt

Reductions in cardiac action potential wavelength, and the consequent wavebreak, have been implicated in arrhythmogenesis. Tachyarrhythmias are more common in the Brugada syndrome, particularly following pharmacological challenge, previously modelled using Scn5a(+/-) murine hearts. Propagation latencies and action potential durations (APDs) from monophasic action potential recordings were used to assess...

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Identifiers

PMID: 23836691
DOI: 10.1113/jphysiol.2013.254938
PMCID: PMC3779110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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