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Article

Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sex.

Pflugers Archiv : European journal of physiology - 1 Jan 2011

Jeevaratnam Kamalan, Poh Tee Sui, Zhang Yanmin, Rewbury Rebecca, Guzadhur Laila, Duehmke Rudolf, Grace Andrew A, Lei Ming, Huang Christopher L-H

Abstract excerpt

We explored for relationships between SCN5A haploinsufficiency, implicated in clinical arrhythmogenicity, and right ventricular (RV) conduction disorders in Langendorff-perfused, male and female, and young (3 months) and old (>12 month old) Scn5a ( +/-) and wild type (WT) hearts. The investigated conditions of genotype, age, and sex affected latencies but not repolarization time courses of RV monophasic action...

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PMID: 21127902
DOI: 10.1007/s00424-010-0906-1
PMCID: PMC3016216

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