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Article

The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3.

Scientific reports - 11 Sept 2017

Chadda Karan R, Ahmad Shiraz, Valli Haseeb, den Uijl Ingrid, Al-Hadithi Ali Bak, Salvage Samantha C, Grace Andrew A, Huang Christopher L-H, Jeevaratnam Kamalan

Abstract excerpt

Long QT Syndrome 3 (LQTS3) arises from gain-of-function Nav1.5 mutations, prolonging action potential repolarisation and electrocardiographic (ECG) QT interval, associated with increased age-dependent risk for major arrhythmic events, and paradoxical responses to β-adrenergic agents. We investigated for independent and interacting effects of age and Scn5a+/ΔKPQ genotype in anaesthetised mice modelling LQTS3 on...

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Identifiers

PMID: 28894151
DOI: 10.1038/s41598-017-11210-3
PMCID: PMC5593918

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