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Article

Light phase-restricted feeding slows basal heart rate to exaggerate the type-3 long QT syndrome phenotype in mice.

American journal of physiology. Heart and circulatory physiology - 15 Dec 2014

Schroder Elizabeth A, Burgess Don E, Manning Cody L, Zhao Yihua, Moss Arthur J, Patwardhan Abhijit, Elayi Claude S, Esser Karyn A, Delisle Brian P

Abstract excerpt

Long QT syndrome type 3 (LQT3) is caused by mutations in the SCN5A-encoded Nav1.5 channel. LQT3 patients exhibit time of day-associated abnormal increases in their heart rate-corrected QT (QTc) intervals and risk for life-threatening episodes. This study determines the effects of uncoupling environmental time cues that entrain circadian rhythms (time of light and time of feeding) on heart rate and ventricular...

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Identifiers

PMID: 25343952
DOI: 10.1152/ajpheart.00341.2014
PMCID: PMC4269698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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