Article
Global Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses.
BMC genomics - 8 Jul 2013
Hanna Nabil, Ouahrani-Bettache Safia, Drake Kenneth L, Adams L Garry, Köhler Stephan, Occhialini Alessandra
Abstract excerpt
BACKGROUND: In the intracellular pathogen Brucella spp., the activation of the stringent response, a global regulatory network providing rapid adaptation to growth-affecting stress conditions such as nutrient deficiency, is essential for replication in the host. A single, bi-functional enzyme Rsh catalyzes synthesis and hydrolysis of the alarmone (p)ppGpp, responsible for differential gene expression under...
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