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The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB.

Cellular microbiology - 1 Nov 2006

Dozot Marie, Boigegrain Rose-Anne, Delrue Rose-May, Hallez Régis, Ouahrani-Bettache Safia, Danese Isabelle, Letesson Jean-Jacques, De Bolle Xavier, Köhler Stephan

Abstract excerpt

Physiological adaptation of intracellular bacteria is critical for timely interaction with eukaryotic host cells. One mechanism of adaptation, the stringent response, is induced by nutrient stress via its effector molecule (p)ppGpp, synthesized by the action of RelA/SpoT homologues. The intracellular pathogen Brucella spp., causative agent of brucellosis, possesses a gene homologous to relA/spoT, named rsh,...

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PMID: 16803581
DOI: 10.1111/j.1462-5822.2006.00749.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB.PMID 16803581Read ↗

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